The mod_wsgi package can be compiled for and used with most recent patch revisions of Apache 2.0, 2.2 or 2.4 on UNIX like systems, such as Linux and MacOS X, as well as Windows.

It is highly recommended that you use Apache 2.4. Older versions of Apache have architectural design problems and sub optimal configuration defaults, that can result in excessive memory usage in certain circumstances. More recent mod_wsgi versions attempt to protect against these problems in Apache 2.0 and 2.2, however it is still better to use Apache 2.4.

Any of the single threaded ‘prefork’ or multithreaded ‘worker’ and ‘event’ Apache MPMs can be used when running on UNIX like systems.

Both Python 2 and 3 are supported. The minimum recommended versions of each being Python 2.6 and 3.3 respectively. The Python installation must have been installed in a way that shared libraries for Python are provided such that embedding of Python in another application is possible.

The mod_wsgi package should be able to host any Python web application which complies with the WSGI specification (PEP 3333). The implementation is very strict with its interpretation of the WSGI specification. Other WSGI servers available aren’t as strict and allow Python web applications to run which do not comply with the WSGI specification. If your Python web application doesn’t comply properly with the WSGI specification, then it may fail to run or may run sub optimally when using mod_wsgi.